Distinction between autoimmune and nonautoimmune hyperthyroidism by determination of thyrotropin-receptor antibodies in patients with the scintigraphic diagnosis of disseminated autonomy.
نویسندگان
چکیده
p53 stability by Mdm2. Nature 387:299–303. 8. Haupt Y, Maya R, Kazaz A, Oren M 1997 Mdm2 promotes the rapid degradation of p53. Nature 387:296–299. 9. Honda R, Yasuda H 1977 Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 420:25– 27. 10. Farid NR 1996 Molecular pathogenesis of thyroid carcinoma: The significance of oncogenes, tumor suppressor genes, and genomic instability. Exp Clin Endocrinol & Diab 104(Suppl 4):1–12. 11. Boros P, Juhasz F, Szegedi G, Kraszits E, Stenszky V, Farid NR 1989 Immunogenetic and immunologic studies of differentiated thyroid carcinoma. Cancer 63:1318–1326. 12. Geng Y, Yu Q, Sicinska E, Das M, Bronson RT, Sicinski P 2001 Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice. Proc Natl Acad Sci USA 98:194–199. 13. Peerer DS, Upton TM, Ladha MH, Neuman E, Zalivde J, Bernards R, De Caprio JA, Ewen ME 1997 Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein. Nature 386:177–181. Y. Shi1 M. Zou1 E. Varkondi2 A. Nagy3 L. Kozma2 Nadir R. Farid4
منابع مشابه
Sporadic Nonautoimmune Neonatal Hyperthyroidism Due to A623V Germline Mutation in the Thyrotropin Receptor Gene
Neonatal hyperthyroidism is a rare disorder and occurs in two forms. An autoimmune form is associated with maternal Graves' disease, resulting from transplacental passage of maternal thyroid-stimulating antibodies and a nonautoimmune form is caused by gain of function mutations in the thyrotropin receptor (TSHR) gene. Thyrotoxicosis caused by germline mutations in the TSHR gene may lead to a va...
متن کاملThe role-playing autoantibodies in autoimmune thyroid diseases and their extra-thyroidal manifestations: review article
The presence of the antibodies against the main thyroid antigens, which include thyroid peroxidase (TPO) or microsomal antigen, thyroglobulin (Tg) as well as thyrotropin receptor or Thyroid Stimulating Hormone Receptor (TSH-R), is a hallmark and symbol of the autoimmune thyroid diseases (AITDs) as one of the most common autoimmune diseases (AD) around the world. The prevalence of the thyroid pe...
متن کاملThe measurement technologies of thyrotropin receptor antibodies from the past to the present
Thyroid Stimulating Hormone Receptor (TSH-R) autoantibodies are the main cause of Graveschr('39') disease and its external thyroid manifestations such as ophtalmopathy and dermatopathy. These antibodies are functionally different and are commonly called TSH receptor antibodies (TRAbs). In fact, TRAbs are a set of autoantibodies including TSHR-stimulating antibodies (TSAbs), TSHR- blocking antib...
متن کاملAnticardiolipin Antibodies and Immunoglobulin M and A in Graves’ Disease
Background: Graves’ disease is an autoimmune disease, characterized by the presence of antibodies directed to TSH receptor or nearby regions as well as antibodies to double strands DNA (dsDNA) anticardiolipin and nuclear antibodies. This study evaluated anticardiolipin and rheumatoid factor, such as IgA and IgM antibodies in patients with Graves’ disease. Patients and methods: Anticardiolipin a...
متن کاملTRAb NEGATIVE ENTITIES OF HYPERTHYROID SYN- DROME – OUR EXPERIENCE OF THE PAST 5 YEARS
Over the past fi ve years, since we moved to private practice, we continued with testing of TSH receptor antibodies. So far we have carried out 775 tests and examined 260 patients. We used TRAb human, BRAHMs. We carried out our research on 192 patients with untreated immune hyperthyroidism and 37 with the disease in remission. As the subject of this study was TRAb negative hyperthyroidism, the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Thyroid : official journal of the American Thyroid Association
دوره 11 7 شماره
صفحات -
تاریخ انتشار 2001